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KMID : 1035520230110030191
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Brain Tumor Research and Treatment : BTRT
2023 Volume.11 No. 3 p.191 ~ p.203
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Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker
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Kim Yu-Jin
Choi Woo-Seok
Sim Jeong-Min
Ahn Ju-Won
Park Jeong-Man
Kim Dong-Kil
Jeong Ju-Yeon
Lee Ji-Min
Michael Salna
Moon Jong-Seok
Moon Ju-Hyung
Yuming Ning
Lim Jae-Joon
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Abstract
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Background : Inflammasomes are key in the initiation of inflammatory responses and serve to defend the organism. However, when the immune system is imbalanced, these complexes contribute to tumor progression. The purpose of this study was to investigate the effect of non-canonical inflammasomes on glioma malignancy.
Methods : We performed bioinformatics analysis to confirm the expression of canonical and non-canonical inflammasome-related molecules according to the degree of malignancy through immunohistochemical examination of glioma tissues obtained with patient consent from our institution.
Results : Bioinformatics analysis confirmed that the expression levels of non-canonical inflammasome-related molecules were significantly higher in tumor tissues than in normal tissues, and they also increased according to malignancy, which adversely affected the survival rate. Furthermore, in gliomas, positive correlations were found between N-form gasdermin-D, a key molecule associated with the non-canonical inflammasome, and other related molecules, including NLRP3, caspase-1, caspase-4, and caspase-5. These results were verified by immunohistochemical examination of glioma tissues, and the expression levels of these molecules also increased significantly with increasing grade. In addition, the features of pyroptosis were confirmed.
Conclusion : This study identified the potential of non-canonical inflammasomes as aggressiveness markers for gliomas and presented a perspective for improving glioma treatment.
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KEYWORD
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Glioma, Inflammasomes, Disease progression, Biomarkers, Pyroptosis
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